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E. Alison Holman

Professor of Nursing

E. Alison Holman studies the early post-event predictors of co-morbid trauma-related mental and physical health problems.

Areas of Expertise

  • Physical health
  • Acute Stress
  • Acute Stress & Cardiovascular Disease
  • Psychological Trauma
  • Media Exposure


E. Alison Holman's research focuses on understanding the early post-event predictors of comorbid trauma-related mental and physical health problems. She seeks to identify predictors of, contributions of, and interactions between acute responses to trauma (biological, cognitive, emotional, social, environmental, behavioral) that increase vulnerability to trauma-related health problems, especially cardiovascular disease. Toward this end, Holman examines gene-environment interactions and the roles of several biological systems in acute/posttraumatic stress response: renin-angiotensin-aldosterone, endocannabinoid, and oxytocin systems as well as hypothalamic-pituitary-adrenal axis response. The ultimate goal is to identify targets for early interventions to prevent trauma-related morbidity and mortality.


Watch on YouTube: 2019 Leider Lecture - E. Alison HolmanWatch on YouTube: Coping with cascading threats: A  study of responses to  COVID-19 | Alison Holman, PhD | UCI


U.C. Irvine

PhD, Health Psychology, 1996

University of California, Santa Cruz

BA, Psychology, 1989

San Francisco State University

BS, Nursing, 1981


  • International Society for Traumatic Stress Studies
  • Association for Psychological Science
  • American Psychological Association, Divisions of Health Psychology and Trauma Psychology
  • California Association for Nurse Practitioners

Research Grants

Genetic variation, stress, and functional outcomes after stroke rehabilitation

National Institute of Nursing Research, 7/1/2015-6/30/2020

A national longitudinal study of community trauma exposure

National Science Foundation, 1/1/2015-12/31/2017

RAPID: Responding to Terror of a Different Kind: A National Study of the Ebola Epidemic

National Science Foundation, 12/1/14 - 11/30/15

Susceptibility to Acute Stress and Cardiovascular Ailments: A Gene-Environment Analysis

Robert Wood Johnson Foundation Nurse Faculty Scholar Grant, 2010-2013